Alprostadil, yakadanwa zvakare sePGE1, imhando yezvigadzirwa zvemishonga, iyo inoshandiswa zvakanyanya mukurapa neminda ine hukama.Inowanikwa sejekiseni kana muchimiro che suppositories uye topical creams yekurapa.Sechimwe chezvikamu zvikuru zvinoshandiswa mukugadzirwa kweprostaglandin E1 (PGE1) derivatives, alprostadil inobata basa rinokosha mukuderedza mitsipa nekuvandudza kuyerera kweropa mune dzimwe nzvimbo dzenyama kune varwere vane erectile dysfunction (ED).Zvidzidzo zvemakiriniki zvakagumisa kuti alprostadil inobudirira inosimudzira erections nekusunungura nitric oxide, iyo inokurudzira masero akatsetseka emhasuru anobatanidzwa mukugadzirisa erection.Uyezve, yakaratidza kushanda zvakakurumidza kudarika mishonga yechinyakare yemuromo kana ichishandiswa intracavernously kana intraurethrally.
Mukutaura kwechiito chemishonga, alprostadil inonyanya kuita seprostaglandin receptor agonist, uye prostaglandin receptors inowanikwa mumuviri womunhu wose.Ichi chiito chinobudisa migumisiro yakadai sevasodilation, zvichiita kuti kuwedzerwa kweropa kuwedzere;bronchoconstriction kuderedza zviratidzo zveasthma;zvinogona kuderedza apoptosis mune zvirwere zvine chokuita nekenza;kuderedza kuzvimba, nezvimwe.Hunhu hwayo huzhinji hunoita kuti ive chinhu chakanakira zvirongwa zvakasiyana siyana zvekuvandudza zvinodhaka, kubva kuED kurapa kuenda kurapwa kenza uye nezvimwe, zvichienderana nedambudziko chairo chigadzirwa chekupedzisira chinofanira kugadzirisa.
Pamusoro pekugadziridzwa kune zvinangwa zvekurapa zvezvirwere zvakasiyana-siyana kuburikidza nenzira dzekutonga dzakadai sejekiseni kana suppository mafomu;kana zvichienzaniswa nezvigadzirwa zvakafanana pamusika, PGE1 inoratidzawo milder side effects, kusanganisira kutemwa nemusoro mushure mekushandisa, kusvika Total kushaya simba mushure memaawa mashomanana;kunyange zvazvo dzimwe nguva dzichiitika, dzinowanzoita zvishoma nezvishoma maererano nemishonga inotarwa, kutanga nemirairo yekushandiswa kwenguva refu inopiwa nereferensi yechiremba.Uyezve, maererano nemiedzo yesayenzi ichangoburwa yakaitwa pasi rose, kazhinji, nguva yekutanga kuita chiito inosiyana kubva pamaminitsi e15 chete kusvika pakukwirira kwemaminetsi makumi matatu, asi sezvineiwo mhedzisiro yacho inoenderana zvakanyanya nemurwere wega wega mamiriro enyaya.
Pakazere, PGE1 yakaratidza hunhu hunoshamisa hunobatsira, kunyanya muvarume vane hutsinye hwekuita pabonde uye matambudziko emamiriro emuviri Mishonga yagara ichitemerwa yakundikana nekuda kwekushaikwa kwesimba rinoshanda uye kuoma kwenyaya dzazvino kunoda kugadziriswa zvakakwana, pasina kunetseka nezve chero hutano hwakakomba. matambudziko, kunyanya kuita kuti ive yakachengeteka uye inoshanda sarudzo.
Nguva yekutumira: Mar-06-2023