Orlistat 96829-58-2 Antiobesity Diet yekuwedzera
Kubhadhara:T/T, L/C
Kwakabva Chigadzirwa:China
Shipping Port:Beijing/Shanghai/Hangzhou
Kukwanisa kugadzira:800kg / mwedzi
Order(MOQ):25kg
Nguva Yekutungamira:3 Mazuva Ekushanda
Mamiriro ekuchengetedza:Kuchengetwa munzvimbo inotonhorera, yakaoma, tembiricha yekamuri.
Package zvinhu:ngoma
Pakeji saizi25kg / chigubhu
Mashoko ekuchengetedza:Kwete zvinhu zvine ngozi
Nhanganyaya
Orlistat ndeyekureba-inobata uye ine simba chaiyo gastrointestinal lipase inhibitor.Ichena kana kuti ingangoita chena poda patembiricha yekamuri, isinganyungudika mumvura, inonyungudika muchloroform, uye inonyungudika nyore mu ethanol.Iyo inactivates iyo enzyme nekugadzira covalent zvisungo neanoshanda serine nzvimbo dzegastric lipase uye pancreatic lipase mudumbu uye mudumbu madiki.
Orlistat imhando ye lipase inhibitor uremu-kurasikirwa mushonga.Iyo hydrated derivative ye lipsstatin, iyo inogona kuderedza kubatwa kwemafuta ekudya uye kuderedza uremu.Ichi chigadzirwa chine inhibition yakasimba uye yakasarudzika yegastric lipase uye pancreatic lipase, haina mhedzisiro pane mamwe ma enzymes ekugaya (amylase, trypsin, chymotrypsin) uye phospholipase, uye haikanganisi kubatwa kwemakhahydrates, mapuroteni uye phospholipids.Iyo inactivates the enzyme kunyanya kuburikidza ne covalent kusunga ne serine residues panzvimbo dzinoshanda dzegastric lipase uye pancreatic lipase mudumbu remukati, inhibits hydrolysis ye triacylglycerol, inoderedza kudyiwa kwe monoglyceride uye yakasununguka mafuta acid, uye nokudaro inodzora uremu hwemuviri.Mushonga wacho hauna kutorwa nemudumbu, uye inhibition ye lipase inogadziriswa.
Ichi chigadzirwa chinewo basa rekugadzirisa ropa lipids.Inogona kuderedza triglyceride uye yakaderera-density lipoprotein cholesterol muserum yevarwere vakafuta uye kuwedzera chiyero chepamusoro-density lipoprotein kune yakaderera-density lipoprotein.
Kana orlistat yakasanganiswa neyakaderera calorie chikafu, inokodzera kurapwa kwenguva refu kwevanhu vakafuta uye vakafutisa, kusanganisira avo vakagadzira kufutisa kwakabatana nenjodzi.Iine huremu hwehuremu hwenguva refu senge kurema, kuchengetedza uremu uye rebound kudzivirira.Iyo kiriniki inoratidza zviripachena kuti huremu basa rekudzora uremu rinobatsira zvakanyanya pakushandiswa kwenguva refu kana kambani ine chikafu kana mushure meawa imwe yekudya.
Orlistat inogona kuderedza huwandu hwehuwandu hwekufutisa hunoenderana nenjodzi uye zvimwe zvirwere zvine chekuita nekufutisa, zvinosanganisira hypercholesterolemia, Type II chirwere cheshuga, kusagadzikana kweglucose kushivirira, hyperinsulinemia, hypertension, uye kuderedza mafuta ari munhengo.
Tsanangudzo (USP42)
| Item | Tsanangudzo |
| Identification | HPLC, IR |
| Specific optical rotation | -48.0°~-51.0° |
| Mvura yemvura | ≤0.2% |
| Zvinoenderana zvinhu I | Orlistat inoenderana nemubatanidzwa A ≤0.2% |
| Zvinhu zvinoenderana II | Orlistat ine hukama B ≤0.05% |
| Zvinhu zvinoenderana III
| Formylleucine ≤0.2% |
| Orlistat inoenderana nechikamu C ≤0.05% | |
| Orlistat yakavhurika mhete epimer ≤0.2% | |
| D-Leucine orlistat ≤0.2% | |
| Kusachena kusingazivikanwe kwemunhu ≤0.1% | |
| Zvinoenderana zvinhu IV | Orlistat inoenderana nemubatanidzwa D ≤0.2% |
| Orlistat yakavhurika mhete amide ≤0.1% | |
| Zvinoenderana zvinhu V | Orlistat inoenderana nechikamu E ≤0.2% |
| Kusachena kwakazara (I kusvika V) | ≤1.0% |
| Residual solvents | Methanol ≤0.3% |
| EtOAc ≤0.5% | |
| n-Heptane ≤0.5% | |
| Residue pakubatidza | ≤0.1% |
| Heavy metals sePb | ≤20ppm |
| Kuongororwa neHPLC | 98.0% ~ 101.5% (pane anhydrous, solvent-isina hwaro) |
